PORTAL, Antoine. Observations sur la nature et le traitement de l'apoplexie, et sur les moyens de la prévenir. 1811.

First edition.
Antoine Portal (1742-1832) was doctor, anatomist, biologist, medical historian and first doctor of Louis XVIII and Charles X. He was part of the creation of the Academy of Medicine.
The subject of this treatise is stroke; a fairly general term at the time that refers to a sudden, more or less complete suspension of brain activity, most often caused by brain haemorrhage.